<sub id="t56hh"></sub>

    期刊文献+

    《世界胃肠病学杂志:英文版》

    作品数21276被引量22468H指数27
    《世界胃肠病学杂志:英文版》
    本刊主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报。查看详情>>
    • 主办单位百世登出版集团有限公司
    • 国际标准连续出版物号1007-9327
    • 出版周期年48期
    共找到21,276篇文章
    < 1 2 250 >
    每页显示 20 50 100
    Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer 认领
    1
    《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2010年第19期共7页
    AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (... AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Associa... 展开更多
    在线阅读 免费下载
    Outcome of surgical treatment of intestinal perforation in typhoid fever 认领
    2
    作者 Aziz Sümer zgür Kemik Ahmet Cumhur Dülger Aydemir Olmez Ismail Hasirci Erol Kisli Vedat Bayrak Gulay Bulut etin Kotan 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2010年第33期共5页
    AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated r... AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively.RESULTS:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or constipation.Sixteen cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair foll... 展开更多
    在线阅读 免费下载
    Is early limited surgery associated with a more benign disease course in Crohn’s disease? 认领 被引量:1
    3
    作者 Petra Anna Golovics Laszlo Lakatos +11 位作者 Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第43期7701-7710,共10页
    AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospi... AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P【0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P【0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. 展开更多
    关键词 Crohn’s DISEASE EARLY SURGERY DISEASE COURSE DISEASE behavior Treatment strategy
    在线阅读 免费下载
    Clinical application of microRNA in gastric cancer in Eastern Asian area 认领 被引量:1
    4
    作者 Ming Gao Hao Yin Zhe-Wei Fei 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第13期2019-2027,共9页
    Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South ... Recent research has shown that microRNA (miRNA), which is involved in almost every step of gastric carcinogenesis, has broad prospective application in diagnosis and therapy of gastric carcinoma. Eastern Asia (South Korea, Japan and China) has the highest incidence of gastric cancer in the world. There were 988 000 new cases of gastric cancer worldwide and 736 000 deaths in 2008. Approximately 60% of the cases of gastric cancer are found in East Asia (mainly China). We herein provide a brief review of the clinical applications of miRNA, which include the following aspects: (1) miRNA may serve as a potential new generation of tumor markers; (2) a complete miRNA expression profile is highly specific, can reflect the evolutionary lineage and differentiation of tumors, and be used to carry out diversity analysis; (3) detecting specific miRNA expression in peripheral blood will become a new method for diagnosis of gastric cancer; (4) miRNA can predict prognosis of gastric cancer; (5) miRNA has predictive value in determining chemotherapy and radiotherapy resistance; and (6) miRNA could be a type of innovative drug. Finally, we focus on assessing the value of miRNA from laboratory to clinical application and the challenges it faces in East Asia. 展开更多
    关键词 MICRORNA PROGNOSIS Clinical application GASTRIC cancer EASTERN ASIA
    在线阅读 免费下载
    Diagnostic value of endothelial markers and HHV-8 staining in gastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging 认领
    5
    作者 Naoyoshi Nagata Toru Igari +8 位作者 Takuro Shimbo Katsunori Sekine Junichi Akiyama Yohei Hamada Hirohisa Yazaki Norio Ohmagari Katsuji Teruya Shinichi Oka Naomi Uemura 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS 2013年第23期3608-3614,共7页
    AIM: To clarify the diagnostic values of hematoxylin and eosin (HE), D2-40, CD31, CD34, and HHV-8 immunohistochemical (IHC) staining in gastrointestinal Kaposi’s sarcoma (GI-KS) in relation to endoscopic tumor stagi... AIM: To clarify the diagnostic values of hematoxylin and eosin (HE), D2-40, CD31, CD34, and HHV-8 immunohistochemical (IHC) staining in gastrointestinal Kaposi’s sarcoma (GI-KS) in relation to endoscopic tumor staging. METHODS: Biopsy samples (n = 133) from 41 human immunodeficiency virus-infected patients were reviewed. GI-KS was defined as histologically negative for other GI diseases and as a positive clinical response to KS therapy. The receiver operating characteristic area under the curve (ROC-AUC) was compared in relation to lesion size, GI location, and macroscopic appearances on endoscopy. RESULTS: GI-KS was confirmed in 84 lesions (81.6%). Other endoscopic findings were polyps (n = 9), inflammation (n = 4), malignant lymphoma (n = 4), and condyloma (n = 2), which mimicked GI-KS on endoscopy. ROC-AUC of HE, D2-40, blood vessel markers, and HHV-8 showed results of 0.83, 0.89, 0.80, and 0.82, respectively. For IHC staining, the ROC-AUC of D2-40 was significantly higher (P 【 0.05) than that of HE staining only. In the analysis of endoscopic appearance, the ROC-AUC of HE and IHC showed a tendency toward an increase in tumor staging (e.g. , small to large, patches, and polypoid to SMT appearance). D2-40 was significantly (P 【 0.05) advantageous in the upper GI tract and for polypoid appearance compared with HE staining. CONCLUSION: The diagnostic value of endothelial markers and HHV-8 staining was found to be high, and its accuracy tended to increase with endoscopic tumor staging. D2-40 will be useful for complementing HE staining in the diagnosis of GI-KS, especially in the upper GI tract and for polypoid appearance. 展开更多
    关键词 Gastrointestinal Kaposi’s SARCOMA HEMATOXYLIN and EOSIN CD31 CD34 D2-40 Human herpesvirus-8
    在线阅读 免费下载
    Effect of hepatic glucose production on acute insulin resistance induced by lipid-infusion in awake rats 认领 被引量:2
    6
    作者 LingLi Gang-YiYang 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2004年第21期3208-3211,共4页
    AIM: To explore the influence of hepatic glucose production on acute insulin resistance induced by a lipid infusion in awake rats. METHODS: A hyperinsulinaemic-euglycaemic clamp was established in awake chronically ca... AIM: To explore the influence of hepatic glucose production on acute insulin resistance induced by a lipid infusion in awake rats. METHODS: A hyperinsulinaemic-euglycaemic clamp was established in awake chronically catheterized rats. Two groups of rats were studied either with a 4-h intraarterial infusion of lipid/heparin or saline. Insulin-mediated peripheral and hepatic glucose metabolism was assessed by hyperinsulinaemic-euglycaemic clamp combined with [3-^3H]-glucose infusion. RESULTS: During hyperinsulinaemic-euglycaemic clamp,there was a significant increase in plasma free fatty acid (FFA, from 741.9±50.6 to 2346.44±238.5μmol/L, P<0.01) in lipid-infused group. The glucose infusion rates (GIR) in the lipid infusion rats, compared to control rats, were significantly reduced (200-240 min average: lipid infusion; 12.64±1.5 vs control; 34.04±1.6 mg/kg.min, P<0.01), declining to - 35% of the corresponding control values during the last time of the clamp (240min: lipid infusion; 12.04±1.9 vs control; 34.74±1.7 mg/kg·min, P<0.0001). At the end of clamp study,the hepatic glucose production (HGP) in control rats was significantly suppressed (88%) from 19.04±4.5 (basal) to 2.34±0.9 mg/kg.min (P<0.01). The suppressive effect of insulin on HGP was significantly blunted in the lipid-infused rats (200-240 min: from 18.74±3.0 to 23.24±3.1 mg/kg.min (P<0.05). The rate of glucose disappearance (GRd) was a slight decrease in the lipid-infused rats compared with controls during the clamp.CONCLUSION: These data suggest that lipid infusion could induces suppression of hepatic glucose production, impairs the abilities of insulin to suppress lipolysis and mediate glucose utilization in peripheral tissue. Therefore, we conclude that lipid-infusion induces an acute insulin resistance in vivo. 展开更多
    关键词 葡萄糖代谢 肝脏 抵抗作用 胰岛素 急性作用 脂质灌输 苏醒 老鼠 导管插入
    在线阅读 免费下载
    Metastatic liver cancer: A rare case 认领 被引量:2
    7
    作者 Bong-Wan Kim Hee-Jung Wang +2 位作者 In-Ho Jeong Sang-Ick Ahn Myoung-Wook Kim 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2005年第27期4281-4284,共4页
    Hemangiopericytoma is a rare tumor especially when it rises in the peritoneal cavity. We present a case of a 60-year-old woman with an isolated recurrent hemangiopericytoma of the liver. The patient presented with a p... Hemangiopericytoma is a rare tumor especially when it rises in the peritoneal cavity. We present a case of a 60-year-old woman with an isolated recurrent hemangiopericytoma of the liver. The patient presented with a palpable right upper quadrant abdominal mass, which occurred 7 years after undergoing resection of a malignant hemangiopericytoma arising from the greater omentum. She had not followed up 6 mo after surgery. Various imaging studies showed a single large, well-capsulated liver tumor with central necrosis, accompanied by hypervascularity typical of a vascular tumor. Preoperative laboratory HBsAg and anti-HCV workup were both negative. Under the impression of recurrent malignant hemangiopericytoma, right trisegmentectomy was performed to completely resect the tumor. Pathological examination confirmed the diagnosis of recurrent hemangiopericytoma. Even though the incidence of the hemangiopericytoma is relatively low, malignant hemangiopericytoma has a tendency to recur frequently after a long-term disease-free interval. Also, the recurrent hemangiopericytoma is not easily detected early during follow-up until it becomes symptomatic because there are no specific tumor markers, and because of the diversity with regard to site of recurrence. The authors suggest that Positron Emission Tomogram (PET) may be a useful tool for the detection of recurrent hemangiopericytoma. We describe herein some characteristics and behaviors of malignant hemangiopericytoma, particularly after surgical resection. 展开更多
    关键词 肝癌 病理机制 病例报告 血管外皮细胞瘤
    在线阅读 免费下载
    Interleukin-lO and chronic liver disease 认领 被引量:1
    8
    作者 Li-Juan Zhang Xiao-Zhong Wang 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2006年第11期1681-1685,共5页
    关键词 白细胞介素-10 慢性肝脏疾病 病理机制 治疗
    在线阅读 免费下载
    Incidence and mortality of gastric cancer in China 认领 被引量:63
    9
    作者 Ling Yang 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2006年第1期17-20,共4页
    胃的癌症是在世界上的最经常的癌症之一;几乎三分之二个胃的癌症盒子和死亡在更少的发达区域发生。在中国,基于在1970年代和1990年代进行的二国家死亡调查,有在这个国家的胃的癌症的地域分布的一个明显的聚类,与死亡主要是在农村区... 胃的癌症是在世界上的最经常的癌症之一;几乎三分之二个胃的癌症盒子和死亡在更少的发达区域发生。在中国,基于在1970年代和1990年代进行的二国家死亡调查,有在这个国家的胃的癌症的地域分布的一个明显的聚类,与死亡主要是在农村区域定位了的高度,特别在 Gansu ,河南省, Hebei ,在中国的中间西方的部分的山西和 Shaanxi 省。尽管有到 1990 年代初的从 1970 年代的细微增加,在胃的癌症死亡的显著衰落被注意在几乎全部人口在在中国的最后十年期间。在经济改革二十年以前开始了以后,这些衰落大部分由于在社会经济的环境,生活方式,营养,教育和护理系统的戏剧的改进。不过,胃的癌症将当前仍然是重要癌症负担并且在中国是在癌症预防和控制策略的关键问题之一。在 2005,从胃的癌症的 30 万死亡和 40 万个新盒子将评价第三很普通的癌症,这被预言。为在中国的胃的癌症的预防和控制策略的必要包裹将集中于控制 Helicobacter pylori (H。pylori ) 感染,改善教育层次,倡导的健康食谱和反烟草竞选,寻找划算的早察觉,诊断和治疗为可医好的管理和辩解的照顾包括途径编程序。 展开更多
    关键词 胃癌 中国 死亡率 病理机制
    在线阅读 免费下载
    Interaction between enteric epithelial cells and Peyer's patch lymphocytes in response to Shigella lipopolysaccharide: Effect on nitric oxide and IL-6 release 认领
    10
    作者 Jie Chen Chuen-Pei Ng +4 位作者 Dewi K Rowlands Peng-Hui Xu Jie-Ying Gao Yiu-Wa Chung Hsiao-Chang Chan 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2006年第24期3895-3900,共6页
    瞄准:在氮的氧化物的版本上调查在伤寒上皮细胞和 Peyer 的补丁的淋巴细胞之间的相互作用的效果(没有) 并且响应志贺氏菌属脂肪的多糖(LPS ) 的 IL-6。方法:人的结肠的上皮细胞(Caco-2 ) 是有 Peyer 的补丁从的淋巴细胞的混合 cocultu... 瞄准:在氮的氧化物的版本上调查在伤寒上皮细胞和 Peyer 的补丁的淋巴细胞之间的相互作用的效果(没有) 并且响应志贺氏菌属脂肪的多糖(LPS ) 的 IL-6。方法:人的结肠的上皮细胞(Caco-2 ) 是有 Peyer 的补丁从的淋巴细胞的混合 cocultured 野类型(C57 老鼠) 并且可诱导没有 synthase 大美人老鼠,并且与志贺氏菌属 F2a-12 LPS 质问了。版本没有并且 mIL-6 被 Griess 比色测定和连接酶的免疫吸着剂试金(ELISA ) 分别地测量。结果:当 LPS 挑战不在时,不在 Caco-2 上皮细胞的培养基然而并非在 Peyer 的补丁的淋巴细胞被检测,并且 NO 版本在有从也的淋巴细胞的两 cocultures 是进一步起来调整的野类型或 i NOS 大美人老鼠,与一显著地,高水平与 i NOS 猛烈淋巴细胞在 coculture 观察了。在为 24-h 的志贺氏菌属 F2a-12 LPS 挑战以后,没有生产显著地从野类型的老鼠然而并非从 i NOS 猛烈老鼠与 Peyer 的补丁的淋巴细胞在独自一个的 Caco-2 和 coculture 被增加。LPS 被发现从淋巴细胞刺激 mIL-6 的版本,它被 coculture 与 Caco-2 上皮细胞压制。在从 i NOS 猛烈老鼠的淋巴细胞的导致 LPS 的 mIL-6 生产从野类型的老鼠比那显著地大。结论:Peyer 的补丁的淋巴细胞从伤寒维持没有生产的组成的基础水平上皮的房间 Caco-2。从 Peyer 的补丁的淋巴细胞的导致 LPS 的 mIL-6 版本被 cocultured 上皮细胞压制。当没有变化在在淋巴细胞从的没有生产是可检测的时野类型并且在 LPS 前后的 i NOS 猛烈老鼠质问,不从淋巴细胞看起来起一个禁止的作用在上皮响应 LPS 的没有版本和他们的自己的 mIL-6 版本。 展开更多
    关键词 肠上皮细胞 囊依赖性淋巴细胞 志贺氏菌病 脂多糖
    在线阅读 免费下载
    Sustained low diffusing capacity in hepatopulmonary syndrome after liver transplantation 认领 被引量:2
    11
    作者 Graciela Martínez-Pallí Federico P Gómez Joan A Barberà Miquel Navasa Josep Roca Robert Rodríguez-Roisin Felip Burgos Conchi Gistau 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2006年第36期5878-5883,共6页
    瞄准:与肝肺症候群(HPS ) 在病人在肝移植(副) 以后学习持续低弥散量(DL (公司)) 的存在。方法:有 mild-to-severe HPS 的六个病人并且 24 没有 HPS,经历了副的人,有希望地在期中考试在副前后被跟随(中部, 15 瞬间) 。HPS 病人也在... 瞄准:与肝肺症候群(HPS ) 在病人在肝移植(副) 以后学习持续低弥散量(DL (公司)) 的存在。方法:有 mild-to-severe HPS 的六个病人并且 24 没有 HPS,经历了副的人,有希望地在期中考试在副前后被跟随(中部, 15 瞬间) 。HPS 病人也在 long-tem 被估计(中部, 86 瞬间) 。结果:在副前, HPS 病人显示出更低的 PaO ( 2 )( 71 +/- 8 毫米汞柱),更高的 AaPO ( 2 )( 43 +/- 10 毫米汞柱)并且更低的 DL (公司)(9%预言了的54%+/-),由于 moderate-to-severe 通风灌注( V (A) /Q )的联合不平衡,温和分流和散开限制 non-HPS 病人( 94 +/- 4 毫米汞柱和 19 +/-3%预言了的 3 毫米汞柱,和85%+/-,分别地)( P【0.05 各个)。七个 non-HPS 病人也减少了 DL (公司)(4% 预言了的 70%+/-) 。在在副以后中间、长期与副前相比, HPS 病人使 PaO ( 2 )正常化( 91 +/- 3 毫米汞柱和 87 +/- 5 毫米汞柱), AaPO ( 2 )( 14 +/- 3 毫米汞柱和 23 +/- 5 毫米汞柱)并且没有在 DL (公司)的变化的所有 V (A) /Q 描述符( P【0.05 各个)(53%+/-7%预言了的8%和56%+/-,分别地)。在有副前的 non-HPS 病人的副以后的 DL (公司) 低 DL (公司) 是未改变的(6% 预言了的 75%+/-) 。结论:当在 HPS 的完全的 V (A)/Q 分辨率显示一个可逆机能障碍时,在在一些 non-HPS 病人,也在场的副以后的持续低 DL (公司) 指向无临床症状的导致肝的肺的脉管的变化的坚持。 展开更多
    关键词 容量 肝移植 一氧化碳 肺交换
    在线阅读 免费下载
    Dynamic changes and mechanism of intestinal endotoxemia in partially hepatectomized rats 认领 被引量:1
    12
    作者 Cui-Ping Xu Juan Liu +3 位作者 Jin-Chun Liu De-Wu Han Yang Zhang Yuan-Chang Zhao 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2007年第26期3592-3597,共6页
    瞄准:探索肠的 endo 血毒症(IETM ) 的机制形成和它的变化在部分 hepatectomized (PH ) 老鼠。方法:一个 -- 102 只成年男 Wistar 老鼠随机被划分成三个组:正常控制(NC ) 组,部分 hepatectomized (PH ) 组和假冒操作(那么) 组。学... 瞄准:探索肠的 endo 血毒症(IETM ) 的机制形成和它的变化在部分 hepatectomized (PH ) 老鼠。方法:一个 -- 102 只成年男 Wistar 老鼠随机被划分成三个组:正常控制(NC ) 组,部分 hepatectomized (PH ) 组和假冒操作(那么) 组。学习动态变化,老鼠在部分肝切除术以后被牺牲在前并且在不同时间点或假冒操作(6 h, 12 h, 24 h, 36 h, 48 h, 72 h, 120 h 和 168 h ) 。NC 组被用作时间指向观察的 0h,也就是 0 h 组。因为每次点显示了,六只老鼠在平行被使用。内毒素(et ) 和二胺氧化酶(DAO ) 铺平与发色的底层和分光光度测定法用鲎属溶解产物测试在浆液被决定。肠粘膜障碍在 opticcal 或电子显微镜下面被观察。数字和在改革肝的残余的 Kupffer 房间(KC ) 的功能的状态被免疫测量组织化学的染色。结果:浆液 et 层次显著地与 NC 相比并且那么在 PH 以后在 6-72 h 时期期间增加了组,并且当浆液 DAO 水平显著地在 12 和 24 h 增加了时,在 12 和 48 h 有二山峰价值。有积极关联(r = 0.757, P 【 0.05 ) 在 DAO 和 et 的层次之间动态变化。光考试在 PH 以后在 6-24 h 时期期间在肠粘膜显示出绒毛的嗜中性的着边和表层坏死。渗透的电子显微镜考试证明在肠粘膜房间之间的差距被增加,镧(La ) 粒子在 6-48 h 时期期间在肠粘膜房间之中被观察。在改革肝的残余的 KC 的数字显著地在 PH 以后在 24-168 h 时期期间被增加。然而, KC 的激活主要在 PH 以后在 48 h 被观察。结论:在 PH 老鼠的 IETM 的机制可能是肠粘膜障碍的损害和象 KC 的功能的状态的消沉一样的 KC 的绝对数字的减少。这观察具有在经历肝切除术的病人的潜在的价值。 展开更多
    关键词 肝切除手术 肠内毒素 肠黏膜 治疗
    在线阅读 免费下载
    Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease 认领 被引量:6
    13
    作者 Miguel Gueimonde Arthur Ouwehand +2 位作者 Heikki Huhtinen Eeva Salminen Seppo Salminen 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2007年第29期3985-3989,共5页
    瞄准:描绘 bifidobacterial 在有结肠癌,煽动性的肠疾病或 diverticuitis 的病人的结肠的粘膜的微生物区系。方法:远侧的结肠的粘膜的一件样品从 34 个病人,的一个总数在外科期间被拿 21 与诊断颜色表面的癌症,九与憩室炎并且四与... 瞄准:描绘 bifidobacterial 在有结肠癌,煽动性的肠疾病或 diverticuitis 的病人的结肠的粘膜的微生物区系。方法:远侧的结肠的粘膜的一件样品从 34 个病人,的一个总数在外科期间被拿 21 与诊断颜色表面的癌症,九与憩室炎并且四与煽动性的肠疾病,为他们的条件要求外科。细菌的 DNA 从联系 mucosa 的微生物区系是的 resected 粘膜样品和 bifidobacterial 被提取借助于质、量的 PCR 决定的品质上和份量上。结果:Bifidobacteria 与憩室炎或 IBD 从病人在样品的 100% 被发现并且 76% 那些受苦的结肠癌。种类 B。渴望嗯并且 B。两岐嗯大多数广泛地被发现,由 B 列在后面。动物是, B。catenulatum 和 B。青少年是。B。倍全音符, B。dentium 和 B。angulatum 没在任何样品被检测。B 的显著地更高的出现。长嗯与结肠癌或 IBD 比在那些与憩室炎在病人被观察(100% , 62% 和 75% ,分别地 P 【 0.05 ) 。类似的结果为 B 被获得。动物是(56% , 0% 和 25% , P 【 0.05 ) ,当时 B。青少年是仅仅与结肠癌从病人在粘膜被发现(5 从 21, 24%) 。在量的水平,有显示出的结肠癌或 IBD 的病人降低全部的 Bifidobacterium 的计数(分别地, 4.94 和 5.91 对 6.96 记载房间 / 样品 P 【 0.05 ) 并且种类 B。渴望嗯(4.05 和 4.79 对 6.76, P 【 0.05 ) 比那些与憩室炎。结论:在粘膜的脱离正道联系了微生物区系在不同肠的疾病是在场的。这可以在这些疾病的致病显示微生物区系的一个角色。 展开更多
    关键词 结肠直肠癌 憩室炎 炎性肠病 结肠粘膜 微生物群
    在线阅读 免费下载
    Duration of treatment with 5-aminosalicylic acid compounds 认领
    14
    作者 T Moshkovska JF Mayberry 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2007年第32期4310-4315,共6页
    5-aminosalicylic 酸(5-ASA ) 的发展治疗作为生活,为 ulcerative 的长治疗在 1940 年代从它的起源被考察到现代。这药被设计对待风湿性关节炎,但是与 ulcerative 在九个病人的管理被发现有用。这发现为估计新药的功效作为一个工具先... 5-aminosalicylic 酸(5-ASA ) 的发展治疗作为生活,为 ulcerative 的长治疗在 1940 年代从它的起源被考察到现代。这药被设计对待风湿性关节炎,但是与 ulcerative 在九个病人的管理被发现有用。这发现为估计新药的功效作为一个工具先于临床的试用的出现;作为结果,它缺乏科学严格并且在它结果的演讲是选择的。不过,它在 ulcerative 识别了治疗的未来奠基石。在 1962, sulphasalazine 的第一两倍盲目控制试用在 40 个病人上被进行。结果措施是主观、包括的症状和对直肠的粘膜的一个评价。在 1973,在宽恕的维护的 sulphasalazine 的角色上的开始的二份报纸被出版。使用安慰剂控制并且有一个成层的图案。结果用“对待的一个意愿”被测量途径。64 个病人的英国学习使用了主观、客观的标准估计结果。安慰剂上的病人让恶化在直接疗法上评估病人四次,这成立了基础因为生活长在 ulcerative 与 5-ASA 混合物来临到治疗。然而在 1985,一“在需求上”小 32 个病人的学习建议这条途径可能象连续治疗一样有效。对这个看法的一些支持来自没在宽恕为那些显示出利益到继续的治疗二年或更多的意大利的研究。这些研究识别的中央问题是到治疗在的坚持的长期。很少研究考虑了病人的态度到连续治疗,需要推进调查,这是一个区域。 展开更多
    关键词 大肠炎 大肠溃疡 5氨基水杨酸混合物 治疗持续时间
    在线阅读 免费下载
    CO liberated from CORM-2 modulates the inflammatory response in the liver of thermally injured mice 认领 被引量:3
    15
    作者 Bing-Wei Sun Yan Sun Zhi-Wei Sun Xi Chen 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2008年第4期547-553,共7页
    瞄准:探索共同释放的效果分子[tricarbonyldichlororuthenium (II ) 更暗淡, CORM-2 ] 在一个实验动物的肝的煽动性的回答的变细上的解放公司热损害并且到当模特儿调查联系潜在的机制。方法:36 只老鼠在三个各自的实验被分到三个组... 瞄准:探索共同释放的效果分子[tricarbonyldichlororuthenium (II ) 更暗淡, CORM-2 ] 在一个实验动物的肝的煽动性的回答的变细上的解放公司热损害并且到当模特儿调查联系潜在的机制。方法:36 只老鼠在三个各自的实验被分到三个组。在每个实验,在假冒的组的鼠标( n = 4 )收到的假冒的热损害,而在灼伤的鼠标组织( n = 4 )收到了15%全部的身体表面区域( TBSA )完整厚度的热损害,并且在灼伤+ CORM-2 的鼠标组织( n = 4 )与 CORM-2 的立即的管理收到了一样的热损害( 8 mg/kg , iv )。肝的织物节与苏木精和曙红被染色并且在一台轻显微镜下面检验了。aminotransferases (中高音和著名计算机生产厂商) 和氮的氧化物的层次(没有) 被生物化学的方法测量。肿瘤坏死 factor-alpha (TNF-alpha ) 和 interleukin (IL-1beta ) 活动,和在浆液和织物 homogenates 的 i NOS 和 HO-1 的蛋白质表示被估计。在在试管内实验, Kupffer 房间当面为 4 h 与 LPS (10 mug/mL ) 被刺激或 CORM-2 (10-100 mumol/L ) 的缺席。随后, TNF-alpha 的表示层次和没有生产被估计。结果:支持 inflammatory 调停人(TNF-alpha, IL-1beta,没有) 在浆液和肝,热地受伤的老鼠的 homogenates 被 CORM-2 管理显著地减少。这被减少在 i NOS 的表示伴随当时在肝织物的 HO-1 的表示的增加。在平行,在刺激 LPS 的 Kupffer 房间的上层清液的 TNF-alpha 并且不的集中与 CORM-2 (10-100 mumol/L ) 共同孵化显著地也被减少。组织学的检查证明 CORM-2 能稀释白血球渗入到肝织物。结论:释放球茎的公司调制肝发炎并且显著地由禁止 i NOS 和没有生产的表示在灼伤老鼠保护肝损伤,下面调整支持 inflammatory 调停人的表示(TNF-alpha, IL-1beta ) 。 展开更多
    关键词 一氧化碳 热伤 肝脏 炎症
    在线阅读 免费下载
    Autophagy and ethanol-induced liver injury 认领 被引量:5
    16
    作者 Terrence M Donohue Jr 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2009年第10期1178-1185,共8页
    背景:在 20 年在心脏的外科病人的常规使用以后, aprotinin 最近关于它的安全由于许多担心从市场被撤退了。自从 1998,为很多个原因, aprotinin 一直不在意大利是可得到的。现在的学习介绍在最后 5 年期间在我们的机构使用的一个 ap... 背景:在 20 年在心脏的外科病人的常规使用以后, aprotinin 最近关于它的安全由于许多担心从市场被撤退了。自从 1998,为很多个原因, aprotinin 一直不在意大利是可得到的。现在的学习介绍在最后 5 年期间在我们的机构使用的一个 aprotinin 免费的治疗协议,并且试图以 allogeneic 血产品输送,手术后的血损失和外科的重新探索率验证这个协议的结果。方法:在年期间经历了心脏的外科的 7988 个连续病人上的回顾的学习 2003 2007。所有病人基于 tranexamic 酸,监视的(b)肝磷脂剂量反应, thromboelastography ,在病人的一张精选人口的血小板( PLT )功能分析,和新鲜冻结的血浆( FFP )的(c)使用的(a)常规使用收到了特定的 hemostasis/coagulation 管理, PLT ,并且 desmopressin 根据 hemostasis/coagulation 侧面。从机构的数据库检索的数据是房间(中华人民共和国) , FFP, PLT 输送率,在开始的 12 个手术后的小时的血损失,和外科的重新探索评估的包装的红的数量。结果:中华人民共和国在 40.4% 病人被输(与为选择高风险的潜水艇人口的更高的率) ,在 12.9% 的 FFP 和在 2.6% 的 PLT。外科的重新探索率是 3.7% 。关于历史的控制,中华人民共和国和 FFP 输送的重要减小用关上的电路,照顾凝结测试的点,和二的联合被获得。结论:保存节目的这 aprotinin 免费的血是为 allogeneic 血产品输送抑制的有效策略。 展开更多
    关键词 酒精性肝损伤 自噬 蛋白质分解 乙醇代谢 信号通路 基因产物 内分泌因素 可能机制
    在线阅读 免费下载
    Intestinal microflora molecular markers of spleen-defcient rats and evaluation of traditional Chinese drugs 认领 被引量:2
    17
    作者 Ying Peng Zhuo Wang +3 位作者 Xiao-Bo Li Chun-Fu Wu Jing-Yu Yang Yuan Lu 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2009年第18期2220-2227,共8页
    关键词 胃肠道菌群 传统中药 分子标记 大鼠 PCR技术 健脾 治疗效果 活性化合物
    在线阅读 免费下载
    Travel of a mis-swallowed long spoon to the jejunum 认领 被引量:1
    18
    作者 Yan Song Hua Guo Jian-Yong Wu 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2009年第39期4984-4985,共2页
    Foreign-body ingestion is a relatively common presentation at emergency departments,but long metallic spoon swallowing is an infrequent occurrence.Unlike most cases of foreign-body ingestion,there have been no reporte... Foreign-body ingestion is a relatively common presentation at emergency departments,but long metallic spoon swallowing is an infrequent occurrence.Unlike most cases of foreign-body ingestion,there have been no reported cases of long foreign bodies reaching the jejunum.We report a rare case of a coffee spoon that was swallowed accidentally and passed through the pylorus and duodenal loop and reached the jejunum,with no complications. 展开更多
    关键词 空肠 旅游 紧急情况 十二指肠 异物 并发症 吞食
    在线阅读 免费下载
    Morphological study on colonic pathology in ulcerative colitis treated by moxibustion 认领 被引量:8
    19
    作者 Wu HG Zhou LB +5 位作者 Shi DR Liu SM Liu HR Zhang BM Chen HP Zhang LS 《世界胃肠病学杂志:英文版(电子版)》 SCIE CAS CSCD 2000年第6期861-865,共5页
    AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustio... AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P【0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P【0.001).The goblet cells significantlyincreased(P【0.001);crypt paracrypt abscessor mucosal ulceration was seen(P【0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. 展开更多
    关键词 COLITIS ulcerative/therapy MOXIBUSTION intestinal MUCOSA morphological study
    在线阅读 免费下载
    Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies 认领 被引量:2
    20
    作者 XIA Bing 1, JBA Crusius 2, SGM Meuwissen 2 and AS Pe*ka 2 《世界胃肠病学杂志:英文版》 SCIE CAS CSCD 1998年第5期83-95,共13页
    DISEASEDEFINITIONSeveralcausesexistforinflammationofthegutsuchasinfection,toxin,autoimmunereaction,radiatio... DISEASEDEFINITIONSeveralcausesexistforinflammationofthegutsuchasinfection,toxin,autoimmunereaction,radiationandischemia.Whenn... 展开更多
    关键词 INFLAMMATORY BOWEL disease/epidemiology INFLAMMATORY BOWEL disease/etiology INFLAMMATORY BOWEL disease/genetics INFLAMMATORY BOWEL disease/immunology
    在线阅读 免费下载
    上一页 1 2 250 下一页 到第
    使用帮助 返回顶部 意见反馈
    福利阁导航